IgGを含むB細胞抗原受容体によって使用される明確なシグナル伝達経路

Chisato Wakabayashi¹, Takahiro Adachi, Jurgen Wienands

¹Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan.

Science (New York, N.Y.)

|December 21, 2002

まとめ

IgGの細胞質尾はCD22の阻害を防止し,IgGとIgDとは異なるIgG-BCRシグナル伝達を強化します. これは,病原体に対する免疫のためにIgGの産生を改善する可能性があります.

科学分野:

免疫学免疫学とは
分子生物学は分子生物学である.
細胞シグナル伝達細胞信号伝達

背景:

Bリンパ球抗原受容体 (BCRs) は,免疫反応を媒介する.
異なるBCR同型 (IgM,IgD,IgG) は,イガルファ/イグベタのような共通成分にもかかわらず,独特の信号を発信する.
CD22のような阻害性コレセプターは,BCR信号伝達を調節する.

研究の目的:

抑制性核受容体CD22.2によるBCR信号伝達の微分調節を調査する.
CD22媒介阻害を調節するIgG細胞質尾の役割を決定する.
独特のIgG-BCRシグナル伝達に伴うメカニズムを解明する.

主な方法:

BCRの活性化を測定するためのセルラーシグナリングアッセイ.
タンパク質のリン酸化を評価するためのウェスタン・ブロッティング.
IgGの細胞質尾の変異分析.

主要な成果:

CD22は,IgM-BCRとIgD-BCRを通したシグナリングをダウンモデュレートします.
CD22は,IgG-BCRによるシグナル伝達を阻害しない.
IgGの細胞質尾はCD22のリン酸化を阻害し,その抑制機能を阻害する.

結論:

IgG細胞質尾は,特に,CD22媒介による阻害を防止することによって,IgG-BCRシグナル伝達を強化する.
この強化されたシグナリングは,免疫に不可欠なIgGの効率的な生産に寄与する可能性があります.
これらのメカニズムを理解することで,B細胞の調節とユーモラル免疫に関する洞察が得られます.

さらに関連する動画

12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

3.9K

10:16

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

13.2K

関連する概念動画

01:28

Insulin: The Receptor and Signaling Pathways

2.8K

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...

2.8K

01:31

Antigen Processing Pathways

2.1K

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...

2.1K

01:19

Interactions Between Signaling Pathways

7.2K

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

7.2K

03:14

Notch Signaling Pathway

6.5K

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...

6.5K

02:33

Hedgehog Signaling Pathway

9.8K

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

9.8K

01:28

Diversity of Antigen Receptors

1.4K

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...