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Updated: Jun 18, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: July 1, 2013

HIV-1 Nefは,PACS-1-およびPI3K-調節されたARF6内細胞経路によってMHC-Iをダウンレギュレーションします

Anastassia D Blagoveshchenskaya1, Laurel Thomas, Sylvain F Feliciangeli

  • 1Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

Cell
|January 16, 2003
PubMed
まとめ

ヒト免疫不全ウイルス1型 (HIV-1) のネフタンパク質は,ARF6内細胞経路をハイジャックし,MHC-I分子をダウンレギュレーションし,免疫回避を可能にします. このプロセスには,NEF,PACS-1,PI3Kが関与し,ウイルスの免疫回避のための新しい細胞機構を明らかにしています.

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Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining06:25

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