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Updated: Jan 30, 2026

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Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
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デルタ-9-テトラヒドロカンナビノール (大麻) がベータ阻害の有無で心臓の機能に及ぼす影響
Circulation
|April 11, 1976
まとめ
デルタ-9-テトラヒドロカンナビノール (デルタ-9-THC) は,心拍数を増やし,シストリック時間間隔を変更することにより,心臓のパフォーマンスを大幅に向上させます. ベータブロッカーは,これらの心血管効果を部分的に抑制します.
科学分野:
- 心臓病学 心臓病学
- 薬理学 薬理学とは
- 生理学 生理学とは
背景:
- 大麻の主な精神活性成分であるデルタ-9-テトラヒドロカンナビノール (デルタ-9-THC) は,心血管への影響が知られている.
- デルタ-9-THCが心臓機能に与える正確な影響を理解することは,その生理学的影響を評価するために不可欠です.
研究 の 目的:
- 健康な男性ボランティアの静脈内デルタ-9-THC投与によるシストリック時間間隔 (STI) への影響を調査する.
- デルタ-9-THCに対する心臓の応答を調節するベータアドレナージックブロックの役割を決定する.
主な方法:
- 静脈収縮時間間隔 (STI) は,25mg/kgのデルタ-9-THCの静脈内投与前と後の10人の健康な男性ボランティアで測定されました.
- 測定は,以前にβ-アドレネルジックブロックを受けた9人の追加被験者に繰り返されました.
主要な成果:
- デルタ-9-THCは,心拍数 (32+/- 7拍数/分) を著しく増加させ,全電機性シストル (17+/- 4.2 msec) と左心室内射出時間 (LVETc) (24+/- 4.0 msec) を延長するなど,STIを変化させた.
- 排泄前期 (PEP) は,デルタ-9-THC (17 +/- 5.1 msec) によって著しく短縮されました.
- ベータアドレナージックブロックは,これらの効果を鈍化し,特にPEPの重要な縮小を防ぐことができました.
結論:
- デルタ-9-THCは,血圧や余剰負荷を変えることなく,心拍数増加とSTIの改変によって証明される心臓のパフォーマンスを向上させます.
- ベータ-アドレナジック経路は,デルタ-9-THCの心臓効果を媒介する部分的な役割を果たします.
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