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血液希釈は,進行した心不全の患者で一般的です
Ana-Silvia Androne1, Stuart D Katz, Lars Lund
1Department of Medicine, Columbia University, New York, NY, USA.
Circulation
|January 23, 2003
まとめ
貧血は慢性心不全 (CHF) 患者によく見られ,より悪い結果と関連しています. 血の量増加である血液希釈は,CHFで頻繁に見られ,真の貧血よりも生存率が低いことと関連しています.
科学分野:
- 心臓病学 心臓病学
- 血液学 ヘマトロジ
- 内科内科は,内科の内科である.
背景:
- 慢性心不全 (CHF) 患者では貧血が多く見られ,予後不良と相関しています.
- CHFにおける低血球数は,血量の増加 (血液希釈) または赤血球量の減少 (真の貧血) から生じる可能性があります.
- CHF患者の血液希釈の罹患率と臨床的影響は,依然としてほとんど不明です.
研究 の 目的:
- 慢性心不全患者における貧血と血解の罹患率を調査する.
- 貧血,血液希釈,およびCHFにおける臨床結果との関連を調べる.
- 貧血性CHF患者における予後不良の潜在的メカニズムを探求する.
主な方法:
- 慢性心不全 (CHF) の患者196人のコホートが研究されました.
- 貧血の罹患率と,ニューヨーク心臓協会 (NYHA) の機能クラスとの相関性が評価されました.
- 赤血球と血の量は,赤血球と血の量を測定するために,I131タグのアルバミンを用いた37人の貧血性CHF患者でI131タグのアルバミンを用いた.
主要な成果:
- 貧血は,CHF患者の61%に存在し,NYHAクラスIIの33%からクラスIVの68%に増加しました.
- 貧血性CHF患者の生存率は,貧血でない患者と比較して減少した (P<0.05).
- 貧血患者では46%が血液の希釈を, 54%が真の貧血を患った. 血液希釈は,より高い死亡率または緊急移植 (P<0.04) と関連していました.
結論:
- 血液希釈は,慢性心不全 (CHF) 患者でよく見られる症状です.
- 貧血は,心筋梗塞の悪い予後を予測する有意な予測要因です.
- 血液希釈の患者は,真の貧血の患者よりも悪い結果を示し,その要因として体積過負荷を示唆しました.
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