平面細胞の極性シグナリングにおけるフィデリティ

Dali Ma¹, Chung-hui Yang, Helen McNeill

¹Department of Pathology, Stanford University School of Medicine, Stanford, California 94305-5324, USA.

Nature

|January 24, 2003

まとめ

ドロソフィラの翼毛の極性は,2層のシグナリングシステムにより非常に正確です. FatとFrizzledの経路は,翼毛の正確な,エラーのない整列を保証し,頑丈な発達を実現します.

科学分野:

発達生物学発達生物学について
細胞生物学細胞生物学
遺伝学遺伝学とは

背景:

ドロソフィラの翼毛は,正確な遠極性を示し,ほぼ完璧な平行配列を形成します.
この細胞組織は,適切な組織発達と機能に不可欠です.
平面細胞の極性 (PCP) 信号経路は,このプロセスを調節することが知られている.

研究の目的:

ドロソフィラの翼毛の極性度の高信頼性を裏付ける分子メカニズムを解明する.
PCP信号経路の異なる階層間の相互作用を調査する.

主な方法:

カデリン脂肪とPCPシグナル伝達におけるFrizzled受容体の役割の分析.
細胞間フィードバックループと翼の上皮細胞内の信号伝導の調査.

主要な成果:

この研究では,翼毛の極性を制御する2層のPCPメカニズムが明らかにされています.
Fat Cadherinはグローバル・オリエンテーションを確立し,Frizzledはフィードバックを通じてローカル・セル・セル・アラインメントを媒介する.
Frizzledフィードバックループは,エラーを修正し,組織全体に強固で正確な極性を確保できます.

結論:

FatとFrizzled経路の相互作用により,高度に正確で堅牢な翼毛の極性性が確保されます.
この協力的なセルアラインメントメカニズムは,エラーの修正を可能にし,事実上エラーのない配列につながります.

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