自然,養育,そして人間の病気
Aravinda Chakravarti1, Peter Little
1McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Jefferson Street Building, 2-109, Baltimore, Maryland 21287, USA. aravinda@jhmi.edu
Nature
|January 24, 2003
まとめ
DNAから50年経った今.
科学分野:
- 遺伝学と分子生物学について
- ヒューマン・バイオロジー ヒューマン・バイオロジー
- 病気のエチオロギー 病気のエチオロギー
背景:
- DNAの構造の発見は生物学に革命をもたらした.
- 人間の生物学と一般的な病気を理解することは,依然として大きな課題です.
- 遺伝子と環境の相互作用は完全に解明されていません.
研究 の 目的:
- ヒトの生物学と病気の理解に対するDNA構造の発見の影響を評価する.
- 共通疾患の原因に関する現在の知識の限界を特定する.
- 環境要因をDNAパラダイムに統合するための枠組みを提案する.
主な方法:
- DNA,ヒト生物学,および一般的な疾患に関する科学文献のレビュー.
- 病気のエチオロギーを遺伝学だけで説明する際の限界の分析.
- DNAレベルでの環境影響を統合する概念的枠組みの開発.
主要な成果:
- DNAの発見にもかかわらず,個々のヒトの生物学と一般的な病気の包括的な理解は欠けている.
- "育成"の側面 (環境の影響) は,DNAパラダイムにおける重要なギャップである.
- 環境要因は,DNAレベルでの生物学的プロセスに影響を及ぼすと仮定されています.
結論:
- 環境の影響は,一般的な病気の原因を完全に把握するために,DNAレベルで理解する必要があります.
- 将来の研究は,エピジェネティクスとDNAとの環境相互作用に焦点を当てるべきである.
- 人間の健康と病気の完全な理解のために,環境要因を組み込むためにパラダイムシフトが必要である.
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