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On-Chip Endothelial Inflammatory Phenotyping
Published on: July 21, 2012
タウリンとビタミンCは,若い喫煙者の単細胞および内皮機能障害を修正する
F M Fennessy1, D S Moneley, J H Wang
1Department of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Circulation
|January 29, 2003
まとめ
タウリンとビタミンCのサプリメントは,単細胞-内皮相互作用を調節することによって,若い喫煙者の内皮機能を改善しました. タウリンは,マクロ血管内皮の健康により有意義な有益な影響を及ぼしました.
科学分野:
- 心血管科学の研究について
- 内皮細胞生物学 エンドセル生物学
- 栄養科学とは,栄養科学である.
背景:
- 単細胞-内皮細胞の相互作用は,慢性喫煙のような状態で内皮細胞機能不全に貢献します.
- タウリンとビタミンCは,炎症性ストレスに対する内皮の保護性があることが知られている.
研究 の 目的:
- タウリンとビタミンCが若年喫煙者の内皮機能を回復する効果を調査する.
- これらのサプリメントがモノサイト・エンドセリア相互作用を修正するかどうかを判断する.
主な方法:
- デュプレックス超音波を用いて,内皮に依存した血管拡張を in vivo で評価した.
- ヒト静脈内皮細胞 (HUVEC) と単細胞条件介質 (MCM) を用いて,試験管内で評価された単細胞-内皮細胞相互作用.
主要な成果:
- 若年喫煙者は,非喫煙者と比較して,内皮依存性血管拡張の障害を示した.
- タウリン (1.5g/d) とビタミンC (2g/d) のサプリメントは,この障害を弱めた.
- 喫煙者由来MCMはHUVECから酸化窒素を減少させ,エンドセリン-1の放出を増加させた;タウリン治療は,エンドセリアル酸化窒素合成酵素の上昇調節によってこれらの効果を逆転させた.
結論:
- タウリンサプリメントは,マクロ血管内皮機能にプラスの影響を及ぼします.
- ディスリピデミック状態における内皮機能に対するタウリンの影響に関するさらなる研究が推奨されています.
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