妊娠初期における葉酸サプリメントと複数出産の可能性:人口ベースのコホート研究
Zhu Li1, Jacqueline Gindler, Hong Wang
1The National Centre for Maternal and Infant Health, and the Department of Health Care Epidemiology, Peking University Health Science Centre, Beijing, China.
Lancet (London, England)
|February 8, 2003
まとめ
妊娠中の葉酸のサプリメントは,複数出産のリスクを増加させません. この大規模なコホート研究では,葉酸の使用と双子または高次元の出産の発生との関連は見つかりませんでした.
科学分野:
- 生殖器保健は,生殖器の健康についてです.
- 産婦人科と産婦人科を担当しています.
- 公衆衛生は公衆衛生である.
背景:
- 葉酸のサプリメントは,新生児の神経管の欠陥を予防するために重要です.
- いくつかの研究では,葉酸の使用と多胎児の増加との潜在的な関連が示唆されています.
- この研究は,葉酸の摂取と多胎妊娠との関連を明らかにすることを目的とした.
研究 の 目的:
- 葉酸補給と多胎児の発生率との関係を調査する.
- 妊娠前または妊娠初期に葉酸の使用が複数の妊娠率に影響するかどうかを判断する.
主な方法:
- 中国で242,015人の女性を対象とした人口ベースのコホート研究.
- 葉酸の使用は,妊娠の結果が知られる前に評価されました.
- 多重出産は,葉酸の摂取タイミング (排卵前,受精,受胎後) に関して分析されました.
主要な成果:
- 合計1496例 (0.62%) の複数出産が記録されました.
- 多胎児の発生率は,葉酸を服用している女性では0.59%,服用していない女性では0.65%でした.
- 葉酸使用に関連した複数出産の比率は0.91 (95%CI 0.82-1.00) でした.
結論:
- 妊娠中の葉酸の摂取は,多胎児のリスクの増加と関連していません.
- この発見は,葉酸サプリメントと双子または複数の妊娠率の上昇との関連を裏付けていません.
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