関連する実験動画

Updated: Jul 7, 2026

A Method of Nodose Ganglia Injection in Sprague-Dawley Rat
09:28

A Method of Nodose Ganglia Injection in Sprague-Dawley Rat

Published on: November 25, 2014

5,7-ジヒドロキシトリプタミンの静脈内注射後,ネズミの過食と成長増加

C F Saller, E M Stricker

    Science (New York, N.Y.)
    |April 23, 1976
    PubMed
    まとめ

    デスメチルミリプラミンと5,7-ジヒドロキシトリプタミンで治療された若年ラットは,著しい体重増加とより大きな成人サイズを示しました. これは,カテキオラミンに影響を与えることなく,かなりのセロトニン減少と関連していました.

    さらに関連する動画

    Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury09:58

    Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

    Published on: November 9, 2018

    Solid Phase 11C-Methylation, Purification and Formulation for the Production of PET Tracers09:25

    Solid Phase 11C-Methylation, Purification and Formulation for the Production of PET Tracers

    Published on: October 24, 2019

    関連する概念動画

    Drug Metabolism: Phase II Reactions01:14

    Drug Metabolism: Phase II Reactions

    Phase II reactions are essential for the detoxification and elimination of drugs from the body. These reactions involve the conjugation of parent drugs or their phase I metabolites with endogenous molecules, resulting in more hydrophilic drug conjugates. The primary conjugation reactions in this phase are sulfation and glucuronidation. Both sulfation and glucuronidation typically produce biologically inactive metabolites. However, in some cases involving prodrugs, active metabolites may be...
    Phase II Conjugation Reactions: Overview01:14

    Phase II Conjugation Reactions: Overview

    Conjugation, a key component of phase II biotransformation reactions, is a vital process in drug detoxification. It involves transferring endogenous substances like glucuronic acid, sulfate, and glycine to drugs or their metabolites formed in phase I reactions. These conjugation reactions, often catalyzed by specific enzymes, transform potentially harmful metabolites into inactive, water-soluble forms easily excreted in urine or bile. By enhancing polarity and eliminating pharmacological...
    Phase II Reactions: Methylation Reactions01:17

    Phase II Reactions: Methylation Reactions

    Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
    The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
    Phase II Reactions: Miscellaneous Conjugation Reactions01:19

    Phase II Reactions: Miscellaneous Conjugation Reactions

    Phase II biotransformations are detoxification mechanisms that conjugate xenobiotics with endogenous substances, neutralizing their toxicity.
    A key example involves the conjugation of cyanide ions, which impair cellular respiration and alter hemoglobin into non-oxygen-carrying cyanmethemoglobin. To neutralize this threat, a sulfur atom from thiosulphate is transferred to the cyanide ion, catalyzed by the enzyme rhodanese, resulting in an inactive compound called thiocyanate. The production of...
    Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

    Drug Accumulation During Multiple Dosing: Repetitive IV Injections

    Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
    Chronic Obstructive Pulmonary Disease II: Emphysema01:23

    Chronic Obstructive Pulmonary Disease II: Emphysema

    Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.