まとめ
抗体で覆われた細胞は,通常,受容体が遮断されているため,リンパ性細胞によって破壊されません. しかし,コンプリメントの活性化により,これらの受容体が解禁され,正常な免疫グロブリンG (IgG) が存在しても細胞破壊が可能になります.
科学分野:
- 免疫学 免疫学とは
- 細胞生物学 細胞生物学
- 補足システムシステムです.
背景:
- リンパ性細胞は,抗体依存性細胞媒介性サイト毒性 (ADCC) を媒介する.
- 通常の免疫グロブリンG (IgG) は,リンパ性細胞のIgG受容体を阻害し,ADCCを抑制します.
- 高血清IgGレベルを考慮すると,IgG受容体のインビヴォの役割は不明である.
研究 の 目的:
- ADCCにおけるIgG受容体の解鎖のメカニズムを調査する.
- 特定の条件下で正常なIgGの存在下でADCCが発生できるかどうかを判断する.
- 高いIgG濃度にもかかわらず,IgG受容体のインビヴォ関連性を明らかにする.
主な方法:
- 抗体で覆われた標的細胞に対するリンパ性細胞の細胞毒性を評価するために,in vitroアッセイを用いる.
- 標的細胞の感受性を,抗体と補完体で操作する.
- 正常なIgGの濃度が異なる場合における細胞毒性を定量化する.
主要な成果:
- リンパ球細胞は,正常なIgGを持つ抗体でコーティングされた標的細胞の抑制された溶解を示した.
- 細胞毒性は,標的細胞が抗体と補完体で敏感にされ,正常なIgGが存在する場合でも回復しました.
- 補足媒介によるIgG受容体の解鎖はADCCを容易にする.
結論:
- IgG受容体は,細胞媒介による細胞毒性に対して,in vivoで機能することができる.
- コンプリメントの活性化は,IgG媒介の受容体阻害を克服する上で重要な役割を果たします.
- このメカニズムは,IgG濃度が高い環境で,効果的な免疫監視と標的細胞の除去を可能にします.
関連する概念動画
01:36Humoral Immune Responses
Overview
01:31Immunoglobulin-like Cell Adhesion Molecules
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
01:28Functions of the Lymphatic and Immune System
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
01:20Special Features of Adaptive Immunity
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
01:28Diversity of Antigen Receptors
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
01:24B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...