ベンセ・ジョーンズ骨髄腫患者の評価のための血清検査
Arthur R Bradwell1, Hugh D Carr-Smith, Graham P Mead
1Division of Immunity and Infection, Medical School, University of Birmingham, B15 2TT, Birmingham, UK. a.r.bradwell@bham.ac.uk
Lancet (London, England)
|February 14, 2003
まとめ
血清免疫グロブリンフリーライトチェーン (FLC) アッセイは,ライトチェーン多発性骨髄腫の診断のために尿のベンセ・ジョーンズタンパク質検査を代替することができます. 血清FLC検査は,これらの患者の治療反応のモニタリングに優れた感度を提供します.
科学分野:
- 腫瘍学 腫瘍学
- 臨床化学 臨床化学について
- 免疫学 免疫学とは
背景:
- 尿中のベンズ・ジョーンズタンパク質は,軽鎖多発性骨髄腫を意味する.
- 現在の診断とモニタリングの方法は,尿検査に基づいています.
研究 の 目的:
- 血清フリーライトチェーン (FLC) アッセイの診断およびモニタリングの有用性を,ライトチェーン多発性骨髄腫の伝統的な尿検査と比較するために.
主な方法:
- 血清FLCの定量免疫測定は,尿検査と比較した.
- 軽鎖性骨髄腫の患者224人が試験開始時に検査されました.
- 82人の患者は,血清と尿のFLC濃度の変化をモニターした.
主要な成果:
- 血清FLCアッセイは,診断時に224人の患者全員を正しく特定しました.
- 監視期間中,血清FLCは73人の患者で異常であり続け,尿検査は26人の患者で陰性となった.
- 血清と尿のFLCの変化は一致したが,血清検査は残留疾患を検出するためのより高い感度を示した.
結論:
- 血清FLC検査は,軽鎖多発性骨髄腫における尿ベンセ・ジョーンズタンパク質検査の信頼性の高い代替品です.
- 血清FLC検査は,治療への反応をモニタリングし,残留疾患を検出するためのより敏感な方法を提供します.
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