COMT val158metの遺伝子型は,痛みストレスに対するムオピオイド神経伝達物質の反応に影響する
Jon-Kar Zubieta1, Mary M Heitzeg, Yolanda R Smith
1Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109-0720, USA. zubieta@umich.edu
Science (New York, N.Y.)
|February 22, 2003
まとめ
カテコル-O-メチルトランスフェラーゼ (COMT) の遺伝的変異は,個人が痛みをどのように経験するかに影響します. COMT val158metのポリモルフィズムは,痛みの知覚とストレスに対する感情的反応に影響します.
科学分野:
- 神経科学は神経科学である.
- 遺伝学 遺伝学とは
- 痛みの研究 痛みの研究
背景:
- 痛みとストレスの反応には,複雑な脳と神経化学的相互作用が含まれています.
- 痛みの知覚における個々の差異は大きい.
- カテコロアミンは,ストレスと痛みの調節に重要な役割を果たします.
研究 の 目的:
- カテコル-O-メチルトランスフェラーゼ (COMT) の共通の遺伝子ポリモルフィズムが人間の痛みの反応に与える影響を調査する.
- COMT遺伝子の変異が痛みの知覚に関与する神経化学システムをどのように調節するかを理解する.
主な方法:
- ヒトの参加者におけるカテキル-O-メチルトランスフェラーゼ (COMT) val158metポリモルフィズムを研究した.
- 持続的な痛みの間,地域的なムオピオイドシステムの活動を評価した.
- 測定された感覚的および感情的痛み評価と内部的感情的状態.
主要な成果:
- COMT met158ホモジゴス型遺伝子型を有する個人は,痛みに対するムオピオイドシステムの反応が低下した.
- これらの個人は,より高い感覚的および感情的痛み評価と,より否定的な気分を報告しました.
- 反対の効果は val158 ホモジゴトで観察され,明らかな遺伝的影響を示した.
結論:
- COMT val158metのポリモルフィズムは,人間の痛みの経験に大きな影響を与えます.
- この遺伝的変異は,痛みやストレスへの適応と反応における個体間の違いを説明する可能性がある.
- COMT経路をターゲットにすることで,疼痛管理戦略に新たな道を開くことができます.
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