BCGワクチン接種とアトピーのリスク
Tyra G Krause1, Anders Hviid, Anders Koch
1Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark. tgv@ssi.dk
JAMA
|February 25, 2003
まとめ
乳児のBCGワクチン接種は,アトピーを発症するリスクを軽減するものではありません. この研究では,ワクチンを接種した子どもとワクチンを受けていない子どもの間で,アトピー発症率が有意な差異がないことが判明しました.
科学分野:
- 免疫学 免疫学とは
- 小児科は小児科です.
- 公衆衛生は公衆衛生である.
背景:
- バチル・カルメット・ゲーリン (BCG) ワクチン接種は,アレルギー性疾患から保護するために推奨されます.
- BCGワクチン接種は1990年までグリーンランドで日常的であったが,その撤回により,小児性アトピーの増加の可能性を調査するようになった.
研究 の 目的:
- BCGワクチン接種と子供のアトピー発症との関連を調査する.
- BCGワクチン接種の年齢がアトピーリスクに影響するかどうかを調べる.
主な方法:
- グリーンランドの8歳から16歳の1686人の学童を対象に横断的な研究が行われました.
- 常見の吸入アレルゲンに対する血清IgEレベルは,アトピーを定義するために測定されました.
- BCGワクチン接種状況とワクチン接種時の年齢に関するデータが収集されました.
主要な成果:
- BCGワクチンを接種した子供と未接種の子供の間では,アトピーのリスクに大きな違いは認められなかった (OR,1.03;95%CI,0.72-1.48).
- BCGワクチンが投与された年齢は,アトピー発症のリスクと関連性がないことが示されました (P = .17).
結論:
- 乳児のBCGワクチン接種は,アトピー発症のリスクの低下と関連していません.
- この調査結果は,BCGワクチン接種が,この集団におけるアトピーに対する保護を与えないことを示唆している.
関連する概念動画
Vaccinations
Overview
Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Smallpox
Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.


