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関連する概念動画

Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
Enlargement of the Plasma Membrane01:22

Enlargement of the Plasma Membrane

Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
SNAREs and Membrane Fusion01:43

SNAREs and Membrane Fusion

Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
What are Membranes?01:24

What are Membranes?

A cell's plasma membrane demarcates the cell's borders and determines the nature of its interaction with the environment. Cells exclude certain substances, take in others, and excrete some others in controlled quantities. The plasma membrane must be flexible to allow certain cells, such as red and white blood cells, to change their shape while passing through narrow capillaries. These are the more obvious plasma membrane functions. In addition, the plasma membrane's surface carries markers that...

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Intermediate steps in the formation of neuronal SNARE complexes.

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Rab GTPases and phosphoinositides fine-tune SNAREs dependent targeting specificity of intracellular vesicle traffic.

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関連する実験動画

Updated: May 11, 2026

Cell Electrofusion Visualized with Fluorescence Microscopy
05:02

Cell Electrofusion Visualized with Fluorescence Microscopy

Published on: July 2, 2010

メンブレーン・フュージョンは,

Reinhard Jahn1, Thorsten Lang, Thomas C Südhof

  • 1Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany. rjahn@gwdg.de

Cell
|February 26, 2003
PubMed
まとめ
この要約は機械生成です。

膜融合は,脂質二層を融合させ,重要な生物学的プロセスである. 様々なタンパク質は,脂質の混合を始めるために膜を結びつけることで,この重要な細胞機能を触媒にします.

さらに関連する動画

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy
10:58

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy

Published on: August 24, 2016

Detergent-free Ultrafast Reconstitution of Membrane Proteins into Lipid Bilayers Using Fusogenic Complementary-charged Proteoliposomes.
11:10

Detergent-free Ultrafast Reconstitution of Membrane Proteins into Lipid Bilayers Using Fusogenic Complementary-charged Proteoliposomes.

Published on: April 5, 2018

関連する実験動画

Last Updated: May 11, 2026

Cell Electrofusion Visualized with Fluorescence Microscopy
05:02

Cell Electrofusion Visualized with Fluorescence Microscopy

Published on: July 2, 2010

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy
10:58

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy

Published on: August 24, 2016

Detergent-free Ultrafast Reconstitution of Membrane Proteins into Lipid Bilayers Using Fusogenic Complementary-charged Proteoliposomes.
11:10

Detergent-free Ultrafast Reconstitution of Membrane Proteins into Lipid Bilayers Using Fusogenic Complementary-charged Proteoliposomes.

Published on: April 5, 2018

科学分野:

  • 細胞生物学 細胞生物学
  • バイオケミストリー バイオケミストリー

背景:

  • 膜融合は,2つの脂質二重層が1つに結合する基本的な生物学的プロセスです.
  • このプロセスは,輸送とシグナル伝達を含む様々な細胞機能に不可欠です.
  • 様々なタンパク質が膜融合を触媒化し,特異性と効率性を確保します.

研究 の 目的:

  • タンパク質触媒膜融合の共通の原理と多様なメカニズムを探求する.
  • タンパク質が2層融合のための膜認識,近接,不安定化をどのように媒介するかを理解する.
  • 細胞内融合イベントにおけるタンパク質複合体の規制的役割を強調する.

主な方法:

  • 既知の膜融合イベントの比較分析.
  • 核融合に関与するタンパク質の構造と機能のレビュー.
  • 膜融合中の脂質とタンパク質の相互作用の検討.

主要な成果:

  • 膜融合タンパク質は,構造の多様性にもかかわらず,共通の機能原理を共有しています.
  • タンパク質は最初の膜認識を媒介し,二重層を密接に結びつけます.
  • 脂質/水界面の不安定化と脂質の混合は,核融合の重要な結果である.
  • 細胞内融合は,精密な調節のための複雑なタンパク質アセンブリを伴う可能性があります.

結論:

  • 細胞融合機械は,特定のニーズに合わせて作られていますが,普遍的な原理で動作します.
  • タンパク質触媒は,膜融合の基本的なプロセスを調節するために不可欠です.
  • これらのメカニズムを理解することで,細胞の組織と機能の洞察が得られます.