口腔の健康と外周動脈疾患について
Hsin-Chia Hung1, Walter Willett, Anwar Merchant
1Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Circulation
|March 5, 2003
まとめ
口腔の健康状態の悪さ,特に歯の脱落や歯周病は,外周動脈疾患 (PAD) のリスクの高さに関連しています. この関連性は,既存の歯周病を持つ男性において特に強く,口腔感染症-炎症経路を示唆しています.
科学分野:
- 心血管の健康について
- 口腔医学は,口腔医学というものです.
- エピデミオロジー エピデミオロジー
背景:
- 既存の研究は,口腔衛生の不良を心臓発作や脳卒中などの心血管疾患と関連付けています.
- しかし,口腔の健康と周辺動脈疾患 (PAD) の関連性は,まだあまり研究されていない.
研究 の 目的:
- 口腔衛生の様々な指標と,外周動脈疾患 (PAD) の発生率との関係を調査する.
主な方法:
- 前向きな研究では,45,136人の男性医療従事者を12年間追跡し,心血管の健康と口腔の状態をモニタリングしました.
- PADのインシデント症例は,ベースラインとフォローアップの口腔健康データに関連して特定され,分析されました.
主要な成果:
- 累積的な歯の喪失は,PADを発症するリスクの増加と有意に関連していました.
- 歯周病の病歴はPADリスクを41%高め,フォローアップ中の歯の喪失は39%増加しました.
- 歯の脱落とPADの関連性は,歯周病歴のある男性 (RR 1.88) と,歯周病歴のない男性 (RR 0.92) の間で顕著に強く見られました.
結論:
- 偶発的な歯の脱落は,特に歯周病の個体において,外周動脈疾患 (PAD) の重要な危険因子です.
- これらの発見は,PAD発症に寄与する口腔感染症-炎症経路を支持しています.
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