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Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog
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Published on: November 5, 2014

GTPaseアクティベーターであるDOCK4は,腫瘍発生時に破壊される

Vijay Yajnik1, Charles Paulding, Raffaella Sordella

  • 1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

Cell
|March 12, 2003
PubMed
まとめ

マウスモデルでのゲノム切除は,細胞の結合を調節する遺伝子であるDOCK4が,腫瘍の進行中に破壊されていることを明らかにしています. 変異したDOCK4は細胞結合を弱め,癌の成長を促し,腫瘍発生におけるその役割を強調しています.

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