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Updated: Jul 6, 2026

Isolation of Primary Mouse Retinal Pigmented Epithelium Cells
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Published on: November 4, 2022

スフィンゴリピド生物合成経路を調節することで,光受容体の変性解消を救います

Usha Acharya1, Shetal Patel, Edmund Koundakjian

  • 1Regulation of Cell Growth Laboratory, National Cancer Institute-Frederick, Frederick, MD 21702, USA. acharyau@mail.ncifcrf.gov

Science (New York, N.Y.)
|March 15, 2003
PubMed
まとめ

スフィンゴリピドの代謝を調節することで,フルーツ・フライの変異体における網膜の退化が救われました. 中性セラミダースを標的とし,スフィンゴリピド合成を低下させることで,視力喪失が抑制され,網膜疾患の治療の可能性を示唆した.

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Long-term Monitoring of Oxygen Consumption Rates in Highly Differentiated and Polarized Retinal Pigment Epithelial Cultures08:09

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