血栓性疾患と胎児喪失:メタ分析
Evelyne Rey1, Susan R Kahn, Michèle David
1Department of Obstetrics and Gynecology, Sainte-Justine Hospital, Quebec, Montreal, Canada. evelyne_rey@ssss.gouv.qc.ca
Lancet (London, England)
|March 22, 2003
まとめ
血栓形成障害である血栓形成症は,再発性および非再発性胎児喪失と関連しており,この関連の強さは,血栓形成症のタイプと胎児喪失のタイミングによって異なります.
科学分野:
- 生殖医学は,生殖器医学である.
- 血液学 ヘマトロジ
- 遺伝学 遺伝学とは
背景:
- トロンボフィリアは,胎児喪失の論争の的になる危険因子です.
- この関連の強さは,胎児喪失のタイミングと定義に依存するかもしれません.
研究 の 目的:
- トロンボフィリアと胎児喪失との関連性を評価する.
- この関連が胎児喪失のタイミングや定義によって変化するかどうかを判断する.
主な方法:
- 1975年から2002年の間に発表された31件の研究 (ケース・コントロール,コホート,横断) のメタ分析.
- 関連する文献を検索したメドラインと現在のコンテンツ.
- プールされたオッズ比率 (OR) は,ランダム効果モデルを使用して生成されました.
主要な成果:
- V因子ライデン変異は,早期および遅い再発性胎児喪失,および遅い非再発性胎児喪失と関連していました.
- 活性化タンパク質C抵抗,プロトロンビンG20210A変異,およびタンパク質S欠乏症は,様々なタイプの胎児喪失と有意な関連性を示した.
- メチレンテトラヒドロフォラート変異,タンパク質C,およびアンチトロンビン欠乏症は,胎児喪失と有意に関連していなかった.
結論:
- トロンボフィリアと胎児喪失との関連が確認されています.
- この関連の強さは,特定の血栓形成症と胎児喪失の種類/タイミングによって大きく異なります.
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