重度の肺気腫患者のバルブインプラントによるブロンコスコーピーの体積縮小
Tudor P Toma1, Nicholas S Hopkinson, James Hillier
1Department of Thoracic Medicine, National Heart and Lung Institute, London, UK.
Lancet (London, England)
|March 22, 2003
まとめ
エンドブロンキアル弁は,重度の肺気腫患者のための新しい肺容量減少方法を提供します. この最小侵襲的処置は,パイロット研究で肺機能の有意な改善と許容可能な安全性を示しました.
科学分野:
- 肺内科 肺内科 肺内科
- 胸部外科手術について
- 医療機器 医療機器について
背景:
- 重度の emphysema は肺機能と生活の質を著しく損なう.
- 肺の体積を減らす手術は選択肢ですが,すべての患者に適していません.
- エンドブロンキアル弁は,肺の体積を減らすために侵襲性の少ない代替手段です.
研究 の 目的:
- 重度の肺気腫における肺の体積減少のための片側エンドブロンキアル弁挿入の安全性と有効性を評価する.
- 機能的改善や地域規模の変化を評価するために,手続きの後に.
主な方法:
- 重度の肺気腫の患者8人を対象とした試験試験.
- 片側エンドブロンキアル弁の挿入.
- 肺機能の評価 (FEV1,TLCO) と介入前・後のCTスキャン.
主要な成果:
- 平均FEV1は34% (p=0.028) 増加し,平均TLCOは29% (p=0.017) 増加した.
- CTスキャンは,4人の患者で,実質的な地域的な体積減少を確認しました.
- 2人の患者で一時的な肺胸炎が発生し,他の大きな有害事象は認められませんでした.
結論:
- 片側エンドブロンキアル弁の埋め込みは,重度の肺気腫の肺容量減少を達成するための安全で効果的な方法です.
- この手順は,短期的な安全性で,重要な機能上の利点をもたらします.
- このテクニックは,手術に適さない,または手術を拒否する患者に有効な選択肢を提供します.
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