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Updated: Jul 9, 2026

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome
11:15

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome

Published on: March 2, 2018

ヒストンH3ライシン27メチル化のX不活性化における役割

Kathrin Plath1, Jia Fang, Susanna K Mlynarczyk-Evans

  • 1Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.

Science (New York, N.Y.)
|March 22, 2003
PubMed
まとめ

ポリコンブ群 (PcG) のタンパク質EedとEzh2複合体は,胚細胞と胚外細胞の両方のX不活性化開始時に,不活性X染色体 (Xi) に採用されます. Xist RNAによって媒介されるこの募集は,ヒストンH3ライシン27メチル化につながりますが,遺伝子サイレンスには不十分です.

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