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Updated: May 5, 2026

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
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人間におけるシンバスタチン依存性プラーク安定化の基礎として,機能的に結合されたサイクロオキシゲナーゼ-2/プロスタグランジンEシンタゼを抑制する

Francesco Cipollone1, Maria Fazia, Annalisa Iezzi

  • 1Department of Medicine and Aging, School of Medicine, University of Chieti G. d'Annunzio, Chieti, Italy.

Circulation
|March 26, 2003
PubMed
まとめ

シムバスタチンは炎症を軽減し,大動脈板内のマクロファージにおけるCOX-2/mPGES発現を抑制します. この作用は,マトリックスメタルプロテインアース (MMP) 誘発の破裂を軽減することにより,プラークの安定化に貢献します.

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