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プラズマナトリウレチンペプチド濃度の上昇は,大動脈狭窄の症状の発症を反映しています
Ivor L Gerber1, Ralph A H Stewart, Malcolm E Legget
1Cardiology Department, Green Lane Hospital, Auckland, New Zealand.
Circulation
|April 2, 2003
まとめ
N-ターミナルプロ脳ナトリウレチンペプチド (NT-proBNP) を含むナトリウレチンペプチドの濃度が上昇すると,症状のある大動脈狭窄を意味します. これらのペプチド測定は,疾患の重症度を評価し,大動脈狭窄患者の治療決定を導くのに役立ちます.
科学分野:
- 心臓病学 心臓病学
- バイオマーカー バイオマーカー
- バルブ性心疾患 バルブ性心疾患とは
背景:
- 症状の発現は,大動脈狭窄 (AS) の自然史において極めて重要であり,弁置換を決定する.
- この研究では,ナトリウレチンペプチドのレベル,ASの重症度,および心臓症状の間の関連性を調査しています.
研究 の 目的:
- ナトリウレチンペプチド濃度と大動脈狭窄における疾患の重症度の関連性を評価する.
- ナトリウレチンペプチド濃度がAS患者の心臓症状と相関するかどうかを判断する.
主な方法:
- 74人のAS患者と100人の対照群は,症状評価,心声検査,およびプラズマナトリウレチンペプチド測定 (心房,BNP,N-BNP) を受けました.
- 症状のある患者と無症状の患者,およびニューヨーク心臓協会 (NYHA) クラスの間でペプチドレベルを比較するために統計分析が行われました.
主要な成果:
- 症状のあるAS患者は,無症状の患者 (0.99cm2) と比較して,小動脈弁の面積 (0.71cm2) が小さかった.
- 血のN-BNP濃度は,無症状患者 (33 pmol/L) よりも症状のある患者 (中位112 pmol/L) で有意に高かった.
- 調整されたN-BNPレベルは,症状のあるAS患者では1.74倍高かった. NYHAクラスではレベルが上昇した (P<0.0001).
結論:
- プラズマナトリウレチンペプチドの濃度は,大動脈狭窄症の症状のある患者で上昇しています.
- ナトリウレチンのペプチド測定は,ASの管理において,臨床的およびエコーカルディオグラフィック評価を補完することができる.
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