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Updated: Jul 14, 2026

Monitoring the Assembly of a Secreted Bacterial Virulence Factor Using Site-specific Crosslinking
11:33

Monitoring the Assembly of a Secreted Bacterial Virulence Factor Using Site-specific Crosslinking

Published on: December 17, 2013

モジュラーポリケチド合成酵素におけるインターモジュール通信:リンカー媒介タンパク質-タンパク質認識の構造と変異分析

Pawan Kumar1, Qing Li, David E Cane

  • 1Department of Chemical Engineering, Stanford University, Stanford, California 94305, USA.

Journal of the American Chemical Society
|April 3, 2003
PubMed
まとめ

モジュール型ポリケチド合成酵素 (PKSs) の短いリンカーペアは,コイル・コイル構造を採用する. この相互作用は,効率的な生物合成に不可欠であり,新しいポリケチド生成のために設計することができます.

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Analyzing Dynamic Protein Complexes Assembled On and Released From Biolayer Interferometry Biosensor Using Mass Spectrometry and Electron Microscopy

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Protein Complex Assembly02:41

Protein Complex Assembly

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Ligand Binding and Linkage

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Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
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Bacterial Protein Maturation

Bacterial protein maturation is a tightly regulated process that ensures newly synthesized polypeptides achieve correct functional conformations. This maturation involves a series of modifications, folding events, and quality control steps, often assisted by specialized chaperone proteins.N-Terminal ModificationsThe maturation of bacterial polypeptides begins cotranslationally as the polypeptide exits the ribosome. The first amino acid, N-formylmethionine (fMet), is typically modified at the...