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Brain Imaging Investigation of the Neural Correlates of Emotion Regulation
Published on: August 26, 2011
心房細動と不規則な心室応答が,ヒトの交感神経活動に与える影響
Stephen L Wasmund1, Jian-Ming Li, Richard L Page
1University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, Dallas, TX 75390-9047, USA.
Circulation
|April 19, 2003
まとめ
心房細動 (AF) は,部分的に不規則な心拍による交感神経活動 (SNA) を著しく増加させます. 正常な副鼻腔リズム (NSR) の回復は,心不全の患者に利益をもたらす可能性があります.
科学分野:
- 心臓病学 心臓病学
- 神経科学は神経科学である.
- 電気生理学 電気生理学
背景:
- 心房細動 (AF) の血液動力学的変化は知られているが,神経の変化は不明である.
- AFが交感神経活動 (SNA) を増加させ,不規則な心室応答が交感刺激に寄与すると仮定した.
研究 の 目的:
- 誘発性心房細動 (AF) が交感神経活動 (SNA) に与える影響を調査する.
- AF中の不規則な心室応答が,SNA.増加に寄与するかどうかを判断する.
主な方法:
- 記録されたSNA,血圧 (BP),中枢静脈圧 (CVP) と心拍数は,8人の患者で,正常なシナプスリズム (NSR) と誘発されたAFの間に記録されました.
- 右心房 (RA) のペースを設定し,NSRに変換した患者で不規則なおよび規則的な心房応答をシミュレートしました.
主要な成果:
- SNAはNSRと比較して誘発AFで有意に増加しました (171% vs 100%,P<0.01).
- 不規則なRAペース (RA-不規則) は,通常のペースよりも高いSNA (124%対91%,P=0.03) をもたらしました.
- 誘発されたAFは,BPの低下とCVPの増加の傾向を示した.
結論:
- 誘発されたAFはSNAを著しく上昇させ,部分的には不規則な心室応答による.
- NSRまたはリズム規則性を回復することは,特に心不全の患者にとって利益をもたらす可能性があります.
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