生まれながらの長QT症候群における交感神経の活動
Abu S M Shamsuzzaman1, Michael J Ackerman, Tomas Kara
1Mayo Clinic, Rochester, Minn 55905, USA.
Circulation
|April 16, 2003
まとめ
生まれながらの長QT症候群 (LQTS) の患者は,交感神経系の活動,特に筋肉の血管への活動が低下しています. この発見は,危険な心律不整に彼らの感受性を説明するかもしれない.
科学分野:
- 心臓病学 心臓病学
- 自律神経科学とは
- 遺伝学 遺伝学とは
背景:
- 生まれながらの長QT症候群 (LQTS) は,個人を生命を脅かす不律症に誘発する.
- 交感神経系は,LQTSにおける心血管疾患の引き金に関与しています.
研究 の 目的:
- 生まれながらのLQTSを持つ患者の交感性ニューラルトラフィックを調査する.
- LQTS患者と健康な対照群の間の交感神経の活動を比較するために.
主な方法:
- 12人のLQTS患者と12人のマッチングした健康なボランティアを研究した.
- 心拍数,呼吸,血圧,筋肉の交感神経活動,皮膚の交感神経活動の継続的なモニタリング.
- RRの変動性のスペクトル分析を使用しました.
主要な成果:
- LQTSの患者は,コントロールと比較して,静止時の心拍数,筋交感神経の活動爆発率,および爆発発生率が低いことを示しました.
- 皮膚の交感神経の活動は,グループによって類似していました.
- スペクトル分析により,LQTS患者におけるRR変動の低頻度成分が減少し,高頻度成分が増加することが明らかになった.
結論:
- 生まれながらのLQTSは,筋肉の血管への同情的な駆動の選択的な減少と関連しています.
- この減少した交感性活動は,LQTS患者の心臓にも影響を及ぼす可能性があります.
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