1型ポリオウイルスは,型型ヒトライノウイルス作業量に含まれています
Marc Davies1, Christine Bruce, Kevin Bewley
1National Collection of Pathogenic Viruses, Centre for Applied Microbiology and Research, Salisbury, UK.
Lancet (London, England)
|April 11, 2003
まとめ
実験室でのポリオウイルスの蓄積は,再導入のリスクを伴う. 1型ポリオウイルスはヒトのライノウイルス株で発見され,汚染された材料の緊急のスクリーニングと破壊の必要性を強調しました.
科学分野:
- ウイルス学 ウイルス学 ウイルス学
- 感染症疫学 感染症疫学
- 公衆衛生は公衆衛生である.
背景:
- 世界的な根絶の取り組みにより,野生のポリオウイルスの流通が著しく減少しました.
- 潜在的な再導入経路には,実験室の蓄積物と患者/環境サンプルが含まれます.
- ウイルス株の誤認は,隠されたリスクをもたらす可能性があります.
研究 の 目的:
- 非ポリオウイルスの研究室の蓄積物からポリオウイルスの再導入のリスクを調査する.
- 誤認されたウイルスコレクションにおけるポリオウイルス感染の有病率を評価する.
- ウイルス学研究所の厳格なスクリーニングプロトコルの重要性を強調する.
主な方法:
- 当初,他のウイルスとして特定された"作業量"の分析.
- これらの株内のウイルス病原体の分子検出と血清型決定.
- 汚染された材料のリスク評価.
主要な成果:
- 1型ポリオウイルスは,ヒトライノウイルス血清型として誤って識別された少なくとも4つの実験室の株で検出されました.
- これは,ウイルスリポジトリにおけるクロス汚染または誤認の重大なリスクを示しています.
- この調査結果は,現在のウイルス株管理における脆弱性を強調しています.
結論:
- 見た目上よく特徴づけられたウイルス株におけるポリオウイルスの存在を緊急に評価することは極めて重要です.
- リスクが利益に優れている場合の材料の必要なスクリーニングと破壊が最重要です.
- 不意にポリオウイルスが再導入されるのを防ぐために,警戒を強める必要がある.
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