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運動中の心血管制御:脊髄損傷の人からの洞察
Flemming Dela1, Thomas Mohr, Christina M R Jensen
1Department of Medical Physiology, The Panum Institute, Building 12.4.7, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark. F.Dela@mfi.ku.dk
Circulation
|April 16, 2003
まとめ
中枢神経系が制御されていなくても,運動中に心拍数が増加します. しかし,自律神経系の機能が保たれることは,動的運動中に心臓の出力と血圧の調節が著しく増加するために不可欠です.
科学分野:
- 心血管生理学 心血管の生理学
- 運動科学は運動科学である.
- 神経科学は神経科学である.
背景:
- 動的運動中に心血管制御における中枢神経系,筋肉アフェレンツ,心交感活動の役割を調査した.
- 脊髄損傷 (SCI) 患者と健常な対照群における心拍数と血圧の調節を検査した.
研究 の 目的:
- 動的運動中に心拍数と血圧を制御するメカニズムを理解する.
- 交感神経系障害の度合いが異なる個体における心血管反応を比較する.
主な方法:
- 脊髄損傷 (SCI) (パラペルジーと四肢麻痺) を患った個体と身体能力のある対照群を研究した.
- SCI患者における電気誘発運動とコントロールにおける自発的な運動を活用した.
- 運動中に同様の酸素吸収レベルでの心臓の出力,足の血流,心拍数,血圧をモニタリングする.
主要な成果:
- 心臓の出力量と足の血流はすべてのグループで増加したが,SCIでは安定した.
- 心拍数は主に心拍数の増加を促し,四肢麻痺では脳卒中の量は四肢麻痺でした.
- 血圧はコントロール群では安定したままであったが,SCIでは,特に四肢麻痺では,時間の経過とともに低下した.
結論:
- 運動中に心拍数がゆっくりと上昇することは,中央のコマンドや自律的な入力なしに起こることがあります.
- 無傷な自律神経系は,運動中に心臓の出力と足の血流の大幅な増加に不可欠です.
- 心臓に影響する交感神経系損傷は,働く筋肉の血管拡張により低血圧を引き起こす可能性があります.
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