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Updated: Aug 18, 2026

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
08:46

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

C-Glycosyltransferase UrdGT2は,d-およびl-構成のヌクレオチド結合ロディノースに対して非選択的である

Dirk Hoffmeister1, Gerald Dräger, Koji Ichinose

  • 1Institute for Pharmaceutical Biology, Albert-Ludwigs-University, Stefan-Meier-Strasse 19, 79104 Freiburg, Germany.

Journal of the American Chemical Society
|April 17, 2003
PubMed
まとめ

UrdGT2酵素はC-グリコシド結合を形成し,ロディノース糖をウルダミシンAに結合させます. このプロセスは,独特のダイロディノシルサイドチェーンを持つ新しいウルダマイシンRとSを作り出し,抗腫瘍薬の可能性を拡大します.

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