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Updated: Jul 19, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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ポリケチド合成酵素モジュールにおけるアシルトランスファーゼドメイン交換のメカニズム分析

Marcus Hans1, Andreas Hornung, Agnieszka Dziarnowski

  • 1Department of Chemical Engineering, Stanford University, Stanford, California 94306, USA.

Journal of the American Chemical Society
|May 2, 2003
PubMed
まとめ

ドメインを交換することによってポリケチド合成酵素 (PKSs) を変化させると,産物形成が減少する. この研究では,基底特異性の変化ではなく,ケトシンタゼとACPドメインによる鎖延長障害が主な原因であることが明らかになりました.

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