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関連する概念動画

1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview01:26

1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview

Nitrous acid and nitric acids are two types of acids containing nitrogen, among which nitrous acid is weaker than nitric acid. Nitrous acid with a pKa value of 3.37 ionizes in water to give a nitrite ion and the hydronium ion.
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by water loss...
2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.
Nitrosation of Enols01:19

Nitrosation of Enols

The nitrosation reaction is one of the methods of preparing 1,2-diketones. The enol tautomer of the starting ketone reacts with sodium nitrite in hydrochloric acid, generating the 1,2-diketone after hydrolysis.
Gas Chromatography: Overview of Detectors01:13

Gas Chromatography: Overview of Detectors

Detectors in gas chromatography (GC) help identify and quantify the components of a mixture by translating chemical properties into measurable signals, which are displayed on a chromatogram. Detectors can be categorized into two main types: destructive and non-destructive.
A non-destructive detector allows a sample to be analyzed without altering or consuming it, meaning the sample can be collected after detection for further analysis. Examples include thermal conductivity detectors and...
Gas Chromatography: Types of Detectors-II01:19

Gas Chromatography: Types of Detectors-II

In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
Inorganic Nitrogen Assimilation01:22

Inorganic Nitrogen Assimilation

Nitrogen is an essential element in biological systems, forming a crucial component of proteins, nucleic acids, and other cellular constituents. Many bacteria and archaea acquire nitrogen in the form of nitrate (NO₃⁻) or ammonia (NH₃), which are then assimilated into biomolecules through specific enzymatic pathways.Assimilatory Nitrate ReductionWhen nitrate enters the cell, it undergoes a two-step reduction process known as assimilatory nitrate reduction. Initially, the enzyme nitrate reductase...

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関連する実験動画

Updated: Jul 11, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
07:38

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

Published on: September 25, 2017

N-ニトロゾ化合物:周囲の空気中の検出

D H Fine, D P Rounbehler, N M Belcher

    Science (New York, N.Y.)
    |June 25, 1976
    PubMed
    まとめ

    N-ニトロゾ化合物の1種であるディメチルニトロサミンは,ボルチモアとベルの空気のサンプルで検出されました. この発見は,N-ニトロゾ化合物の新しい,非常に敏感な検出技術を使用したものです.

    科学分野:

    • 環境化学 環境化学
    • アナリティカル・ケミストリー (Analytical Chemistry) とは
    • 毒理学 毒理学 毒理学

    背景:

    • N-ニトロゾ化合物は,発癌の可能性が知られている化学物質のクラスです.
    • N-ニトロゾ化合物の検出のための以前の分析方法には,十分な感度が欠けていました.
    • ディメチルニトロサミンは,環境と健康を懸念する特定のN-ニトロゾ化合物です.

    研究 の 目的:

    • N-ニトロゾ化合物の新しい,高度に選択的な検出技術を開発し,適用する.
    • 環境空気のサンプルにおけるディメチルニトロサミンの存在と濃度を定量化するために.
    • 研究された場所での他の未確認のN-ニトロゾ化合物の発生を調査する.

    主な方法:

    • N-NO結合の触媒分裂とニトロシル基の検出に基づく新しい検出技術が採用されました.
    • この方法により,ピコグラムレベルの感度 (1012分の1分の1) を達成した.
    • ガス-液体クロマトグラフィと高性能液体クロマトグラフィは,確認のために新しい検出器と併用して使用されました.

    主要な成果:

    • ディメチルニトロサミンは,ボルチモア (0.020.96 ppb) とベル (0.0140.051 ppb) の空気サンプルで検出されました.

    さらに関連する動画

    Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System
    07:32

    Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System

    Published on: January 30, 2019

    Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
    08:23

    Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

    Published on: February 16, 2022

    関連する実験動画

    Last Updated: Jul 11, 2026

    A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
    07:38

    A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

    Published on: September 25, 2017

    Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System
    07:32

    Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System

    Published on: January 30, 2019

    Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
    08:23

    Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

    Published on: February 16, 2022

  • フィラデルフィア,ウィルミントン,ウォルサムからの空気サンプルでは,N-ニトロゾ化合物は検出されなかった.
  • 1〜3種類の未確認のN-ニトロゾ化合物もボルチモアとベルで検出されました.

    • 結論:

    • 新しい分析方法は,空気中のN-ニトロゾ化合物の微量レベルを検出するのに非常に有効です.
    • ディメチルニトロサミンは,ボルチモアやベルなどの産業地域の空気中に存在します.
    • 未知のN-ニトロゾ化合物とその源を特定するためにさらなる研究が必要です.