ダイエット繊維と結腸直腸腺腫が結腸直腸がん早期発見プログラムで
Ulrike Peters1, Rashmi Sinha, Nilanjan Chatterjee
1Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, DHHS, MD 20892-7273, USA. petersu@mail.nih.gov <petersu@mail.nih.gov>
Lancet (London, England)
|May 10, 2003
まとめ
食物繊維,特に穀物,シリアル,果物からの高い摂取量は,遠大腸腺腫のリスクの低下と関連しています. この発見は,大腸がんの予防における食事の役割を理解するのに役立ちます.
科学分野:
- 栄養学的流行病学について
- 胃腸内科 胃腸内科
- 腫瘍学 腫瘍学
背景:
- 食物繊維と結腸直腸腺腫/がんのリスクとの関連性については議論されている.
- 以前の研究では,この関係に関して矛盾する結果が得られました.
研究 の 目的:
- 食物繊維摂取量と結腸直腸腺腫を発症するリスクとの関連を調査する.
- 特定の繊維源がこのリスクに影響するかどうかを判断する.
主な方法:
- 前立腺,肺,結腸,卵巣 (PLCO) がんスクリーニング試験のデータを活用した.
- 137項目の食品頻度アンケートを使用して,33,971人のシグモイドスコピー陰性参加者および3,591人の結腸直腸腺腫患者の食物繊維摂取量を評価しました.
- ロジスティック回帰分析を使用して,確率比率を推定し,潜在的な混乱要因を調整しました.
主要な成果:
- 食物繊維の摂取量の増加は,結腸直腸腺腫のリスクの低下と有意に関連していました (最も高いクインチルと最も低いクインチルの27%の減少).
- 逆相関は,穀物,シリアル,果物から得られた繊維で最も顕著でした.
- 繊維摂取量と直腸腺腫のリスクとの間に有意な関連性は認められなかった.
結論:
- 食物繊維,特に穀物,シリアル,果物などの植物由来の食物繊維は,遠結腸腺腫のリスクの低下と関連しています.
- これらの発見は,大腸内腺腫の予防における特定の食事成分の役割を支持しています.
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