慢性的なクロミジア肺炎感染,自己免疫,炎症が冠動脈リスクに与える相乗効果
Tiina Huittinen1, Maija Leinonen, Leena Tenkanen
1National Public Health Institute, Aapistie 1, PO box 310, FIN-90101 Oulu, Finland. tiina.huittinen@ktl.fi
Circulation
|May 14, 2003
まとめ
Chlamydia pneumoniaeとヒト熱ショックタンパク質60の抗体が持続的に上昇し,特に高C反応性タンパク質の抗体は,中年男性の冠動脈事件リスクを大幅に増加させます.
科学分野:
- 心血管科学の研究について
- 免疫学 免疫学とは
- 感染症 感染症とは
背景:
- 動脈硬化症は慢性感染症,自己免疫,炎症と関連しています.
- クラミジア肺炎感染症,ヒト熱ショックタンパク質60 (hHsp60) 抗体,およびC反応性タンパク質 (CRP) が冠動脈リスクに及ぼす影響の組み合わせは,調査を必要とする.
研究 の 目的:
- 慢性的なクロミジア肺炎感染症,持続的に上昇したhHsp60抗体,および冠動脈リスクに対するCRPの共同効果を評価する.
主な方法:
- ヘルシンキ心臓研究における将来的な内蔵症例対照研究.
- 4081人の脱脂症の男性から採取した血清サンプルをC.pneumoniae抗体,hHsp60抗体,CRPレベルに分析した.
- 冠動脈事件 (非致死性心筋梗塞または冠動脈死) は8.5年間追跡されました.
主要な成果:
- C. pneumoniaeまたはhHsp60に対するIgA抗体が持続的に上昇すると,個別に冠動脈事件のリスクが増加します (OR 1.96-2.11).
- このリスクは,抗体値が上昇した状態とCRP値が上昇した状態 (OR 4.36-4.47) の併合で,著しく高かった.
- 暫定的なマーカーではなく,持続的に上昇したマーカーは,リスクの増加と関連していました.
結論:
- 持続的に上昇したC.pneumoniaeおよびhHsp60 IgA抗体は冠動脈事件を予測します.
- これらの抗体は,CRP濃度の上昇とともに存在する場合,予測値は著しく増幅されます.
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