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Updated: Jan 17, 2026

Assembly of Complex Microtubule Structures
01:32

Assembly of Complex Microtubule Structures

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Srs2ヘリケーゼは,Rad51核タンパク質フィラメントを破壊することによって再結合を防ぐ

Xavier Veaute1, Josette Jeusset, Christine Soustelle

  • 1CEA, DSV, Département de Radiobiologie et Radiopathologie, UMR217 CNRS/CEA, BP6, 92265 Fontenay aux Roses Cedex, France. xavier.veaute@cea.fr

Nature
|May 16, 2003
PubMed
まとめ

Srs2ヘリケーゼは,Rad51フィラメントを破壊することによって,有害なDNA再結合を防止します. この研究は,同類の再組み合わせを制御し,ゲノム安定性を維持する新しいメカニズムを明らかにしています.

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Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
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Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
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Microtubules are dynamic structures that undergo continuous assembly and disassembly. They originate from specialized multi-protein complexes known as microtubule organizing centers or MTOCs. Within the MTOC, the point of origin of the microtubule is known as the minus end, while the end radiating outward is the plus end. Microtubules serve two primary functions — the organization of spindle complexes to separate sister chromatids during mitotic or meiotic cell division and the formation...
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Microtubules in Cell Motility

Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
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