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Updated: Jun 24, 2026

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
09:07

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Published on: December 19, 2018

エストロゲン受容体のシグナル伝達の調節は,活性化されたダイオキシン受容体との結合によって行われます

Fumiaki Ohtake1, Ken-ichi Takeyama, Takahiro Matsumoto

  • 1The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.

Nature
|May 30, 2003
PubMed
まとめ

環境汚染物質であるダイオキシンは,エストロゲン受容体 (ERs) と相互作用することで,エストロゲンの効果を模倣することができます. 活性化されたダイオキシン受容体 (AhR) は,ERに結合し,遺伝子転写に影響を与え,有害なエストロゲン作用を引き起こす.

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