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Updated: Jul 8, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

同一のアゴニストが同類の受容体に対して異なる結合方向性を持つのは,ロック&キーか,単純なケイジか?

Ting-Wei Mu1, Henry A Lester, Dennis A Dougherty

  • 1Division of Chemistry and Chemical Engineering and Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

Journal of the American Chemical Society
|June 5, 2003
PubMed
まとめ

研究者は,C. elegansのセロトニン受容体MOD-1を研究した. 彼らは,5-HT3受容体とは異なるトリプトファン残基を使用していることを発見し,結合時にリガンドの再編成を示唆しました.

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Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography09:09

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography

Published on: September 20, 2016

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells14:02

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

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