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Updated: Jul 17, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

コリスマートミュータゼによる速度増強に対するコンフォメーション圧縮と優先移行状態の安定化の貢献

Cristiano Ruch Werneck Guimarães1, Matthew P Repasky, Jayaraman Chandrasekhar

  • 1Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, USA.

Journal of the American Chemical Society
|June 5, 2003
PubMed
まとめ

コリスマートミュータゼ (CM) は,その基質を事前に組織化するのではなく,その基質の接近攻撃形状 (NAC) を圧縮することによって反応を加速します. この酵素触媒による圧縮はエンタルピー的に制御され,酵素触媒で観察された有意な速度向上を説明します.

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