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Updated: Jul 8, 2026

Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast
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コラーゲンの安定性に対する3ヒドロキシプロリン残留物の影響

Cara L Jenkins1, Lynn E Bretscher, Ilia A Guzei

  • 1Contribution from the Department of Chemistry and Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Journal of the American Chemical Society
|June 6, 2003
PubMed
まとめ

この研究では,3-ヒドロキシ-l-プロリン (3-Hyp) が,4-ヒドロキシ-l-プロリン (4-Hyp) と異なり,コラーゲンのトリプルヘリクスを不安定化することが明らかになりました. コラーゲン配列内のその位置は,タンパク質の安定性に対するこの不安定化効果に大きく影響する.

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mRNA Stability and Gene Expression02:51

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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
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