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Updated: Jul 13, 2026

Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors
08:33

Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors

Published on: January 19, 2015

HIV-1逆転写酵素の複合体のモデルを非核酸阻害剤TMC125で検証

Marina Udier-Blagović1, Julian Tirado-Rives, William L Jorgensen

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.

Journal of the American Chemical Society
|June 6, 2003
PubMed
まとめ

HIV-1逆転写酵素に結合するTMC125の構造が決定され,計算で検証されました. これは,野生型および変異性HIVに対する薬剤の効能を確認し,新しいノンヌクレオシド逆転写酵素阻害剤 (NNRTIs) の開発を支援しています.

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