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Updated: Jul 11, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
09:33

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

動的同位体効果は,シトクロムp450で触媒化された水酸化反応において2つの電性酸化物質を伴う

Martin Newcomb1, David Aebisher, Runnan Shen

  • 1Department of Chemistry, University of Illinois at Chicago, 60607, USA. men@uic.edu

Journal of the American Chemical Society
|June 6, 2003
PubMed
まとめ

サイトクロームP450 (P450) 酵素を調査したこの研究では,複数のヒドロキシル化経路を明らかにするために,動的同位体効果を使用しました. この発見は,P450触媒の"二つの状態"モデルよりも"二つの酸化物質"モデルを支持する.

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