結核とインターフェロン・ガンマ遺伝子の多形態NFkappaB結合部位との関連性

Manda Rossouw¹, Hendrik J Nel, Graham S Cooke

¹MRC Centre for Molecular and Cellular Biology and Department of Medical Biochemistry, Faculty of Health Sciences, Stellenbosch University, 7505, Tygerberg, South Africa.

Lancet (London, England)

|June 6, 2003

まとめ

インターフェロンガンマ (IFNG) の特定の遺伝子変異は,結核の感受性に関連しています. この遺伝的要因は宿主の防衛機構に影響を与え,結核の発症に潜在的に影響を及ぼします.

科学分野:

免疫遺伝学免疫遺伝学とは
感染症感染症は感染症です.
分子生物学は分子生物学である.

背景:

インターフェロンガンマ (IFNG) は,様々な感染症に対する宿主の防御に重要な役割を果たします.
IFNG遺伝子内の遺伝的変異は,結核などの感染症に対する感受性に影響を与える可能性があります.

研究の目的:

インターフェロンガンマ遺伝子 (IFNG) の特定のポリモルフィズムと結核の感受性との関連を調べる.
IFNGの遺伝的変動が結核を発症するリスクに影響するかどうかを判断する.

主な方法:

313人の結核患者と南アフリカの人口を対象としたケース・コントロール研究.
131の家族で伝播不均衡テストを用いた家族ベースの研究.
IFNG遺伝子内の+874A-->Tポリモルフィズムに関する分析.

主要な成果:

IFNGにおける+874A-->Tポリモルフィズムと南アフリカの人口における結核との間に有意な関連性が見つかりました (p=0.0055).
この関連性は,家族ベースの研究 (p=0.005) で成功裏に再現されました.
転写因子NFkappaBは,対照群においてより一般的である+874Tアレルに優先的に結合する.

結論:

+874A-->Tポリモルフィズムによって影響されるインターフェロンガンマ発現の遺伝的に決定された変異は,結核の病原性において重要である可能性があります.
この発見は,IFNGの遺伝的変動が結核の感受性における役割を果たすことを示唆している.

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