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Updated: Jul 19, 2026

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS
07:33

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS

Published on: December 21, 2011

耐性動脈のカルシウム感受性の窒素酸化物誘発による低下は,ミオシン光鎖フォスファタゼの活性化に起因し,RhoA/Rhoキナーゼ経路によって対抗する

Steffen-Sebastian Bolz1, Lukas Vogel, Daniel Sollinger

  • 1Physiologisches Institut der Ludwig Maximilians Universität, Schillerstrasse 44, 80336 München, Germany. bolz@lrz.uni-muenchen.de

Circulation
|June 11, 2003
PubMed
まとめ

酸化窒素 (NO) は,ミオシン・ライトチェーン・フォスファターゼ (MLCP) を活性化することで抵抗性動脈を広げ,細胞のカルシウム感受性を低下させます. RhoA経路は,この効果に対抗しますが,Rhoキナーゼ阻害剤は,NO媒介の血管拡張を回復することができます.

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