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Updated: May 5, 2026

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes
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In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes

Published on: August 13, 2012

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甲状腺細胞におけるグルタミン酸とATPによるCFTRのダイナミック選択性の制御

M M Reddy1, P M Quinton

  • 1Department of Pediatrics, UCSD School of Medicine, University of California, San Diego, La Jolla, California 92093-0831, USA. mmr@ucsd.edu

Nature
|June 13, 2003
PubMed
まとめ

サイトプラズミックグルタミン酸は,ATPとリン酸化から独立して,システィック線維症のトランスメブラン伝導性調節器 (CFTR) アニオンチャネルを活性化します. このグルタミン酸で活性化されたCFTRは,二酸化炭素の伝導性を調節し,その喪失は,性線維症の重症に寄与する.

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