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Updated: Jul 8, 2026

EPR Monitored Redox Titration of the Cofactors of Saccharomyces cerevisiae Nar1
06:01

EPR Monitored Redox Titration of the Cofactors of Saccharomyces cerevisiae Nar1

Published on: November 26, 2014

タンパク質チロシンフォスファタゼ1Bのレドックス調節には,スルフェニルアミド中間体が含まれています

Annette Salmeen1, Jannik N Andersen, Michael P Myers

  • 1Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

Nature
|June 13, 2003
PubMed
まとめ

ペロキシド水素は,タンパク質チロシンフォスファタゼ1B (PTP1B) を逆行的に阻害することによって,細胞シグナル伝達を調節する. 新種のサルフェニルアミド改変により,PTP1Bが保護され,この重要な酵素のリドックス制御が可能になる.

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