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Single-cell Suction Recordings from Mouse Cone Photoreceptors
Published on: January 6, 2010
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メラノプシンとロッド・コーン・フォトレセプティブ・システムは,マウスにおけるすべての主要な補助視覚機能を担っている
S Hattar1, R J Lucas, N Mrosovsky
1Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Nature
|June 17, 2003
まとめ
哺乳類の網膜は,ロッドコーン・システムとメラノプシン・システムの両方を視力および昼夜調節のために使用します. これらのシステムは,瞳孔の反射や光の誘導を制御するために協力しています.
科学分野:
- オフタルモロジック (眼科)
- 神経科学は神経科学である.
- クロノバイオロジー クロノバイオロジー
背景:
- 哺乳類の網膜は,ロッドコーン光受容体とメラノプシン発現システムの両方を備えています.
- メラノプシン系は,瞳孔光の反射や昼夜光学誘導などの補助的な視覚機能を媒介する.
- メラノプシンを消去すると,これらの機能が部分的に低下し,他の光受容系が関与している可能性があることを示唆します.
研究 の 目的:
- 哺乳類の補助視覚機能における棒とメラノプシンシステムの役割を調査する.
- 追加の光受容系が瞳孔の光反射と昼夜リズム調節に寄与するかどうかを判断する.
主な方法:
- 棒・コーン切除されたマウスの昼間リズム相変化に対するアクションスペクトルの測定.
- このスペクトルを瞳孔の光反射とメラノプシン光敏感性との比較.
- メラノプシンとロッドコーン光伝導の両方が欠けているマウスの世代.
主要な成果:
- 棒円切除されたマウスの昼間リズム相変化の作用スペクトルは,瞳孔の光反射スペクトルとメラノプシン光敏感性に一致した.
- メラノプシンと機能的な棒を欠いたマウスは,瞳孔反射の完全な障害,光/暗サイクル誘導,および光マスク応答を示した.
結論:
- 棒-円およびメラノプシン光受容系は不可欠であり,補助的な視覚機能におけるすべての光入力に集団的に責任があります.
- この2つのシステムは,瞳孔の光反射,昼夜光学誘導,そして光に対するマスク反応に唯一貢献しているように見えます.
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