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Updated: May 12, 2026

Analysis of the c-KIT Ligand Promoter Using Chromatin Immunoprecipitation
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細胞膜から細胞核へのTGF-β信号伝達のメカニズム

Yigong Shi1, Joan Massagué

  • 1Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA. yshi@molbio.princeton.edu

Cell
|June 18, 2003
PubMed
まとめ

成長因子ベータ (TGF-β) 信号の変換は,動物の発達にとって極めて重要です. このレビューは,TGF-β受容体の活性化,Smadタンパク質の調節,および遺伝子発現機構の理解における最近の進歩を詳細に述べています.

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
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