関連する実験動画

Updated: Jul 17, 2026

In vivo and in vitro Studies of Adaptor-clathrin Interaction
17:14

In vivo and in vitro Studies of Adaptor-clathrin Interaction

Published on: January 26, 2011

単一鎖DNAの進行性AID触媒によるサイトシン脱アミネーションは,ソマティックハイパーミューテーションをシミュレートします

Phuong Pham1, Ronda Bransteitter, John Petruska

  • 1Department of Biological Sciences, Hedco Molecular Biology Laboratories, University of Southern California, University Park, Los Angeles, California 90089-1340, USA.

Nature
|June 24, 2003
PubMed
まとめ

アクティベーション誘発型シチジンデアミナーゼ (AID) は,単一鎖DNAのサイトシンをウラシルにデアミナーし,特定のWRC配列をターゲットにします. この酵素は,個々のDNA鎖に複数のデアミネーションを実行し,抗体遺伝子変異の重要な特徴を説明します.

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Mismatch Repair

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Mismatch Repair01:36

Mismatch Repair

Overview
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Translesion DNA Polymerases

Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
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Homologous Recombination02:31

Homologous Recombination

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Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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Spontaneous and Induced Mutations01:30

Spontaneous and Induced Mutations

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