子どもにおける細菌性髄膜炎
Xavier Sáez-Llorens1, George H McCracken
1University of Panama School of Medicine, Hospital del Niño, Panama City, Panama. xsaezll@cwpanama.net
Lancet (London, England)
|June 27, 2003
まとめ
バクテリア性髄膜炎は,先進国では稀ですが,発展途上国では壊滅的です. この感染症を予防するために,新しい治療法と世界的なワクチン導入のために,研究が不可欠です.
科学分野:
- 小児感染症は,小児の感染症です.
- 微生物学 微生物学とは
- エピデミオロジー エピデミオロジー
背景:
- 細菌性髄膜炎の疫学,微生物学,病理生理学,臨床的表れ,診断,管理,予後,予防は,小児症例に焦点を当てて検討されています.
- 細菌性髄膜炎の景観の変化には,Haemophilus influenzaeの減少,新興の抗生物質耐性Streptococcus pneumoniae,およびNeisseria meningitidisの発生の増加が含まれています.
- pneumococcal と meningococal 髄膜炎に対する結合ワクチンのための重要な研究が進行中です.
研究 の 目的:
- 細菌性髄膜炎の包括的な見直しを行い,小児の患者を強調する.
- 細菌性髄膜炎における進化する課題と研究方向を強調する.
主な方法:
- 疫学,微生物学,病理生理学,臨床的側面,診断,管理,予後,予防に関する文献レビュー.
- 抗生物質耐性,ワクチン開発,世界的な格差を含む最近の傾向の分析.
主要な成果:
- バクテリア性髄膜炎は,先進国では珍しくなっているが,発展途上国では深刻な脅威となっている.
- マルチ薬物耐性およびバンコマイシン耐性肺炎球菌の出現は,髄膜球菌の流行とともに,継続的な課題を提示しています.
- 肺炎球菌と髄膜球菌髄膜炎に対する結合ワクチンの開発は有望である.
結論:
- 進歩にもかかわらず,細菌性髄膜炎は,新しい抗菌剤および抗炎症剤の基礎的および臨床研究を継続する必要があります.
- 効果的なワクチンの世界的な配布と導入は,世界中の細菌性髄膜炎を予防するために不可欠です.
関連する概念動画
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