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心房と心房のエコー中に犬の心房神経節の再入場回路: 電気生理学的および組織学的相関関係
Peter Loh1, Siew Yen Ho, Tokuhiro Kawara
1Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands. p.loh@hli.azu.nl
Circulation
|July 2, 2003
まとめ
この研究では,犬の異なるAVノードル領域が,二重生理学と再入りを可能にすることを明らかにしました. 導導ブロックと遅い導導導は,組織交差点で発生し,心房と心房のエコーを容易にします.
科学分野:
- 心血管電気生理学 心血管電気生理学
- 心臓の解剖学 心臓の解剖学
- アリトモゲネシス アリトモゲネシス
背景:
- アトリオベントリキュラー (AV) ノーダル再侵入の正確な解剖学的根拠は,まだ完全に理解されていません.
- リエントラント回路の位置を特定し,遅い伝導とブロックの場所を特定することは,AVノードル機能を理解するために重要です.
研究 の 目的:
- 隔離された犬の心臓の電気生理学的発見とAVノードルヒストロジーを相関させるため.
- 心房と心房のエコーに責任のある再侵入回路を局所化するために.
- AVノード内の遅い伝導と伝導ブロックの場所を特徴付けるために.
主な方法:
- 細胞外電気活動は,高解像度 (0.3-0.5mmの電子間距離) で,心房組織除去後の10個の孤立した犬の心臓のコッホの三角で記録されました.
- 5つの心臓は,電気記録と組織構造を相関させるため,組織学的検査を受けた.
- リエントラント現象を研究するために,心房と心室のエコーが誘発されました.
主要な成果:
- 片方向の伝導ブロックは,心房エコー中に上部AV節の心房-移行細胞結節で発生しました.
- 遅い伝導ゾーンは,下部AVノードの心房-移行または移行-コンパクトノード交差点で特定されました.
- 室腔エコーでは,上部AVノードのコンパクトノード-トランジション細胞交差点で伝導ブロックが発生し,下部には遅い伝導ゾーンが発生しました.
結論:
- 犬のAVノードの上部と下部の領域の組織構造と機能的な解離は,二重生理と再入りを促進します.
- 遅い伝導と機能的伝導ブロックは,主として,AV結節領域内の異なる組織タイプ間の接点で発生します.
- 心房-過渡とコンパクトノード-過渡の細胞交差点の特定の伝導ブロックサイトは,それぞれ心房と心房のエコーのメカニズムを説明します.
関連する概念動画
01:13The Cardiac Cycle
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The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
01:19Electrophysiology of Normal Cardiac Rhythm
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
01:19Conduction System of the Heart
Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
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The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
01:25Correlation between ECG and Cardiac Cycle
The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
01:20Conduction System of the Heart
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This system relies on the unique properties of nodal and Purkinje cells:...
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01:25ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
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