ペイヤーのパッチ型デンドリート細胞によって,腸に宿るT細胞の選択的インプリント化が行われます
J Rodrigo Mora1, Maria Rosa Bono, N Manjunath
1The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nature
|July 4, 2003
まとめ
Peyer's patch dendritic cellsは,T細胞に特異性のある腸を宿す特異性をインプリントしています. このプロセスは,エフェクター/メモリT細胞が,抗原に出会うために小腸にアクセスすることを許可します.
科学分野:
- 免疫学 免疫学とは
- 細胞生物学 細胞生物学
- 胃腸内科 胃腸内科
背景:
- ネイブT細胞は,通常,二次リンパ性臓器に存在します.
- 抗原の活性化により,T細胞は,非リンパ性組織に移動することができる.
- エフェクター/メモリーT細胞は,好ましくは,最初の抗原との接触に関連した部位を宿している.
研究 の 目的:
- T細胞に腸トロピズムをインプリントするデンドリット細胞の役割を調査する.
- ペイヤーのパッチデンドリット細胞が腸内ホーミング受容体を特異的に誘導するかどうかを判断する.
主な方法:
- CD8+T細胞をペイヤー斑,周辺リンパ節,からのデンドリット細胞で刺激する.
- T細胞活性化マーカーとエフェクタ活性の分析.
- 腸内ホーミング受容体発現 (alpha4beta7,CCR9) と機能の評価.
主要な成果:
- ペイヤー・パッチ・デンドリット細胞は,他のリンパ性臓器の細胞は含まないが,アルファ4ベータ7とCCR9発現の高いレベルを誘発した.
- ペイヤー・パッチ・デンドリット細胞によって刺激されたT細胞は,TECK/CCL25に対する反応性が向上し,小腸への帰着を示した.
- dendritic 細胞源に関係なく,同等の T 細胞活性化とエフェクター機能が観察されました.
結論:
- ペイヤー・パッチのデンドリット細胞は,T細胞に腸内特異性を刻む上で極めて重要です.
- このインプリントは,エフェクター/メモリーT細胞が,抗原が存在する可能性が高い小腸にアクセスすることを可能にします.
- ペイヤー・パッチ・デンドリティック細胞は,T細胞の反応を腸に誘導する上で重要な役割を果たします.
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