炎症は低脂肪低コレステロールダイエットの脂質への影響を変化させる:DASH-ナトリウム試験の結果
Thomas P Erlinger1, Edgar R Miller, Jeanne Charleston
1Department of Medicine, the Johns Hopkins University School of Medicine, Baltimore, Md, USA. terlinge@jhmi.edu
Circulation
|July 9, 2003
まとめ
C反応性タンパク質 (CRP) によって示される炎症は,低脂肪食がコレステロールを下げる効果を低下させる可能性があります. 高いCRPレベルは,総コレステロールとLDLコレステロールの減少とトリグリセリドの増加と関連していました.
科学分野:
- 心血管の健康について
- 脂質代謝についてです.
- 栄養科学とは,栄養科学である.
背景:
- 炎症媒介体は,脂質代謝の調節に重要な役割を果たします.
- 炎症は,食事介入によるコレステロール低下効果を潜在的に相殺する可能性があります.
研究 の 目的:
- 炎症が低脂肪/低コレステロールダイエットのコレステロール低下効果を軽減するという仮説を検証する.
- ベースラインのC反応性タンパク質 (CRP) レベルとDASHダイエットへの反応の関連性を調べる.
主な方法:
- 100人の参加者は2週間の試行期間を経て,ランダムにコントロールまたはDASHダイエットに12週間割り当てられました.
- 中央のC反応性タンパク質 (CRP) レベルは,ベースラインで測定されました.
- 総コレステロール,LDL,HDL,トリグリセリドの変化は,CRPのベースラインレベルとの関係で分析されました.
主要な成果:
- DASHダイエットは,総コレステロール,LDLコレステロール,HDLコレステロールを大幅に低下させましたが,CRPレベルには影響しませんでした.
- ベースラインより高いCRPは,総コレステロールとLDLコレステロールの著しく低い低下と関連していました.
- ベースラインより高いCRPはトリグリセリドの上昇と関連していたが,低CRPの患者では変化は見られなかった.
結論:
- 増加したC反応性タンパク質 (CRP) レベルは,低脂肪食への反応として,コレステロールの減少とトリグリセリドの増加と関連しています.
- これらの発見は,炎症が心血管疾患のリスクを増加させる可能性があるメカニズムであることを示唆しています.
- 炎症状態は,脂質管理のための食事介入の有効性に影響します.
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